Which assessment indicates the desired outcome of losartan therapy?

• A. Serum creatinine remains elevated.
• B. Urine output increases.
• C. Blood pressure decreases toward target range.
• D. Hematocrit increases.

Answer: (C)

Losartan helps lower blood pressure, which is crucial for protecting kidney function in CKD. The best sign that the therapy is working is that blood pressure has decreased toward the target range. This reflects the medication’s effect of reducing systemic and intraglomerular pressures, helping slow kidney damage and reduce cardiovascular risk.

Serum creatinine remaining elevated would indicate ongoing kidney dysfunction rather than successful BP control. Urine output changes are not a reliable measure of losartan effectiveness, and hematocrit is not directly affected by this drug.